TARGETING AGING
Our mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan.
Slowing aging and treating disease
Aging is the fundamental driver of many highly morbid, chronic diseases that reduce both the quantity and quality of life. We believe that intervening directly in the aging process will be the most impactful way to decrease the burden of disease and increase healthspan in an aging population.
Insights from human data
BioAge is mapping human aging from the ground up. We have forged partnerships with unique biobanks containing healthy human samples collected over decades that are paired with extensive follow-up records that include detailed future healthspan, lifespan, and disease outcomes. We are building deep molecular profiles of these samples, incorporating proteomics, metabolomics, and transcriptomics to identify the best drug targets for healthy aging.
BioAge Platform: from Target ID to Therapeutics
Our platform identifies key drug targets that will impact aging. The company’s proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan, and disease outcomes. We have built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. Our pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.
BGE-117: BioAge’s first clinical-stage asset targets HIF signalling
A core longevity pathway that drives regeneration, healing, and resilience
The Hypoxia-inducible factor (HIF) pathway is linked to lifespan and healthspan in BioAge’s proprietary human aging data. Pathway activation levels are significantly associated with longevity and multiple functional measures. BGE-117 is a hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor that can potentially treat multiple diseases of aging through the activation of HIF-1 target genes that are involved in numerous biological processes including tissue regeneration, erythropoiesis, glycolysis, glucose uptake, vascular remodeling and angiogenesis.
Leadership Team
Development Team
Advisors
Board